EUGENE, Ore. (AP) -- Jeremiah Masoli threw for 116 yards and a touchdown and ran for another score before sitting out the second half in No. 16 Oregon's 52-6 victory over Washington State on Saturday night.

Ed Dickson had seven catches for 103 yards and a score for the Ducks (4-1, 2-0 Pacific-10) who won their fourth straight after a season-opening loss at Boise State.

Masoli, who was seen icing his right knee before halftime when backup Nate Costa took over, watched in warmups from the sidelines in the second half but did not appear to be seriously injured.

The Cougars (1-4, 0-3) were held to 139 yards of offense. Oregon had 505 yards.

Freshman quarterback Jeff Tuel made his first start but completed just one of two passes in the first quarter before he was knocked out by a hard sack. He had a hip pointer and did not return.

Dickson, who played only sparingly in the second half, was the Pac-10's player of the week after pulling down three scoring passes last weekend in Oregon's 42-3 upset victory over then-No. 6 California. The victory popped the Ducks into the AP Poll.

Oregon built a 21-0 lead in the first quarter and the rout was on.

LaMichael James got it started for the Ducks with a 26-yard touchdown run less than two minutes into the game.

After Masoli found Dickson with a 26-yard scoring pass, James added a 3-yard TD run to make it 21-0.

Tuel, who showed promise in relief last weekend in the Cougars' 27-6 loss at USC, was shaky in his first start in front of Autzen's notoriously loud crowd.

He was sacked twice. The second, by Oregon's Will Tukuafo, knocked Tuel out of the game. He was replaced by Marshall Lobbestael, who was limited by a sore left knee.

Washington State wide receiver Jared Karstetter also sat out the second half with a hip pointer.

Masoli scored on a 1-yard keeper before Andre Crenshaw's 6-yard touchdown dash. Nate Costa, who replaced Masoli midway through the second quarter, scored on a 4-yard run just before halftime to make it 42-0.

After Morgan Flint kicked a 40-yard field goal for the Ducks, Lobbestael's 1-yard keeper for Washington State late in the third quarter made it 45-6.

Remene Alston scored for Oregon on a 6-yard run to open the final quarter.

Lobbestael completed seven of 13 passes for 47 yards and the TD. He was intercepted twice.

Dickson has 104 career catches, surpassing Josh Wilcox for most career receptions for an Oregon tight end. Wilcox (1993-96) had 103.

The win against the Cougars came the day after some more drama surrounding LeGarrette Blount.

First-year coach Chip Kelly announced Friday that there was a possibility the suspended running back could return this season if he met certain conditions.

Blount was suspended for the season for punching a Boise State player in the aftermath of Oregon's 19-8 season-opening loss to the Broncos. He was allowed to stay on scholarship and practice with the team.

Kelly said Blount must meet academic and behavior conditions before his possible reinstatement, which would not occur until Oregon's Nov. 7 game at Stanford at the earliest.