STANFORD, Calif. (AP) -- LaMichael James ran for 146 yards and three touchdowns and No. 6 Oregon sprinted past third-ranked Stanford 53-30 on Saturday night, giving Andrew Luck's Heisman Trophy campaign a blemish and taking a giant step toward hosting the inaugural Pac-12 championship.
James ran for scores from 1, 4 and 58 yards and had Stanford (9-1, 7-1) defenders slipping all over a slick field. The Ducks (9-1, 7-0) ended the nation's best winning streak at 17 games - which the Cardinal began after a loss in Eugene more than a year ago - and can clinch the league's North Division crown over Stanford with a win in one of their final two games.
Luck threw for 271 yards and three touchdowns with two interceptions and a fumble. Stanford had five total turnovers.
The Quack Attack just has Luck's number.
Oregon's no-huddle, spread-option ended any hopes of Stanford's first national championship. Instead, the Ducks are suddenly back in the BCS title mix after rolling off their ninth straight victory - and first against a top-five team on the road team - since a season-opening loss against top-ranked LSU.
Darron Thomas threw for 155 yards and three touchdowns to anchor one big-play burst after another. He tossed scores of 59 yards to Josh Huff and 41 yards to De'Anthony Thomas to leave sold-out Stanford Stadium stunned and silent.
The Cardinal did little with the few mistakes Oregon made.
James muffed a punt that and gave Stanford a chance at the Oregon 34. The Ducks quickly stifled Stanford again, and Eric Whitaker missed a 48-yard field badly right.
When the Cardinal got the ball back, Terrell Turner smashed Luck and forced the quarterback to fumble. Oregon recovered and James followed with a 4-yard score on fourth-and-2 to give the Ducks a commanding 36-16 lead in the third quarter.
All the Luck in the world couldn't bring Stanford back.
The two offenses traded scores until Boseko Lokombo intercepted a pass by Luck and returned it 40 yards for a touchdown to give the Ducks a 53-30 lead. Luck dived for the tackle at the goal line and got planted in the grass.
Too late again.
While a pair of the nation's highest-scoring offenses showed imperfections, Oregon pounced on the mistakes and ran away with points each time.
James ran through the middle untouched for a 58-yard touchdown to extend Oregon's lead to 15-6 early in the second quarter. The Ducks threatened to pad their lead again until Delano Howell, with a cast around his right hand, punched the ball loose fromand Stanford recovered.
Oregon coach Chip Kelly gambled all night and his offense made him look good.
On fourth-and-7 from the Stanford 41, De'Anthony Thomas took a short pass and raced down the sideline for a 41-yard TD that pushed Oregon in front 22-9 late in the first half. With the Ducks again about to make the game a rout, Luck answered in impressive fashion.
He led an eight-play, 84-yard drive capped by a threaded 13-yard TD pass to Whalen for the second time. The crucial score with 24 seconds remaining in the half trimmed Oregon's lead to 22-16.
It was the first time Stanford trailed at the half since at Notre Dame in 2009, when the Cardinal were down 24-20. Stanford rallied for a 45-38 win in South Bend.
No comeback this time.